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Fig. 5 | Malaria Journal

Fig. 5

From: Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis

Fig. 5

Absolute overestimation in efficacy due to sub-optimal follow-up duration (compared to day 63 estimates). Overestimation of efficacy relative to day 63 estimates for AL and DP regimen. In areas of high transmission, there was a median of 15% new infections in the DP arm and 30% new infections in AL arm representing. In areas of low transmission, there was a median of 8% new infections in the DP arm and 15% new infections in the AL arm. Simulation assumed 500 patients per treatment arm and was repeated for 1,000 runs. AL = artemether-lumefantrine; DP = dihydroartemisinin-piperaquine (See Additional file 1 for further details on the functions used for simulation)

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Malaria Journal

ISSN: 1475-2875

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