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Table 2 Summary PK data of strasseriolides A–D

From: Preclinical evaluation of strasseriolides AD, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251

Strasseriolides Tinitial
(h)
Estimated PK parameter
Plasma Conc. (µM) T1/2
(h)
AUC0−t
(µM x h)
MRT
(h)
Vz_obs
(L/kg)
@Tinitial @T24 h     
A 0.5 0.498 ± 0.29 <0.0048 4.4 1.14 2.98 312.4
B* 0.13 19.6 ± 1.2
C 0.5 0.246 ± 0.023 0.0035 ± 0.0009 6.3 0.766 4.7 636.8
D 1.5 1.247 ± 0.023 0.107 ± 0.005 7.3 10.06 8.0 51.9
  1. Where T1/2 is the apparent terminal elimination half-life time, AUC0-t is the area under the concentration vs. time curve (calculated as sum of AUCs using linear trapezoidal summation from time 0 to the last measurable data point), MRT is the mean retention time, and Vz_obs is the plasma distribution volume
  2. *Only Tinitial and the Plasma Conc @ Tinitial were recorded as all the mice injected with this compound died under 8 min