The association between acute fatty liver disease and nitric oxide during malaria in pregnancy

Malaria Journal

Table 2 Downregulated proteins in the liver of immunized pregnant mice infected with P. berghei NK65

Description	Abbreviation	Uninfected pregnant mouse	Immunized non-pregnant mouse infected with P. berghei NK65	Immunized pregnant mouse infected with P. berghei NK65	Accession
Major urinary protein 2 OS	Mup2	2.28	2.27	0.45	P11589†
Cytochrome P450 2C70 OS	Cyp2c70	1.99	0.97	0.47	Q91W64†
Atypical kinase ADCK3, mitochondrial OS	Adck3	0.62	0.97	0.15	Q60936†
Cytochrome P450 2A4 OS	Cyp2a4	1.77	0.29	0.44	P15392†
Pericentrin OS	Pcnt	0.84	0.67	0.23	P48725†
Fatty acid desaturase 2 OS	Fads2	1.53	0.82	0.45	Q9Z0R9†
Cytochrome P450 2C54 OS	Cyp2c54	0.79	1.11	0.26	Q6XVG2†
Guanidinoacetate N-methyltransferase OS	Gamt	1.41	1.05	0.47	O35969†
3-ketoacyl-CoA thiolase B, peroxisomal OS	Acaa1b	0.66	0.86	0.22	Q8VCH0†
Corticosteroid-binding globulin OS	Serpina6	8.48	0.21	2.84	Q06770†
Cytochrome P450 2C29 OS	Cyp2c29	1.15	1.24	0.39	Q64458†
D-dopachrome decarboxylase OS	Ddt	0.89	1.15	0.30	O35215†
Proteasome subunit beta type-5 OS	Psmb5	1.08	0.76	0.37	O55234†
6.8 kDa mitochondrial proteolipid OS	Mp68	0.88	0.82	0.31	P56379†
Apolipoprotein C-III OS	Apoc3	2.03	1.10	0.77	P33622†
Phenylalanine-4-hydroxylase OS	Pah	0.89	0.84	0.35	P16331†
Fatty acid synthase OS	Fasn	1.31	1.70	0.51	P19096†
Dimethylaniline monooxygenase [N-oxide-forming] 3 OS	Fmo3	2.31	1.41	0.92	P97501†

Protein levels in the livers of immunized pregnant mice infected with P. berghei NK65 were compared with levels in uninfected non-pregnant mice. Proteins with at least three peptide spectral matches and fold change < 0.5 compared with unimmunized non-pregnant mice without infection (naïve virgin mice) are listed. Daggers indicate proteins with significantly lower levels than in unimmunized non-pregnant mice without infection (naïve virgin mice) (< 0.4-fold change). Additional file 1: Table S1 shows all proteins detected in this study. Data are representative of three independent experiments

ISSN: 1475-2875