Table 1 Summary of haematology and parasite data
From: Haematological response in experimental human Plasmodium falciparum and Plasmodium vivax malaria
| Pf all (n = 269) | Pf 3D7 (n = 254) | Pf K13 (n = 15) | P. vivax (n = 46) |
P-value (3D7 vs K13) |
P-value (Pf all vs P. vivax) | |
|---|---|---|---|---|---|---|
| Age, Years (Median, IQR) |
24 (22–28) |
24 (22–28) |
23 (21–27) |
24 (21–31) | 0.38 | 0.87 |
| Male Sex, n (%) | 197 (73) | 188 (74) | 9 (60) | 30 (65) | 0.23 | 0.26 |
| PPPre, Parasites/mL (Median, IQR) |
10,277 (3566–27,815) |
9,008 (3341–21,798) |
71,427 (33,327–180,218) |
34,840 (13,302–77,064) | < 0.0001 | < 0.0001 |
| PP, Parasites/mL (Median, IQR) |
20,218 (8350–55,570) |
18,240 (7901–49,995) |
132,160 (69,160–309,057) |
53,696 (15,934–102,635) | < 0.0001 | 0.0006 |
| TPBPre, Parasites/mL (Median, IQR) |
30,223 a (14,320–90,970) |
28,366 a (12,637–75,571) |
410,274 a (166,853–1,106,184) |
31,345 (12,264–67,516) | < 0.0001 | 0.38 |
| PRR (Median, IQR) |
0.058 (0.045–0.081) |
0.060 (0.045–0.082) |
0.051 (0.045–0.055) |
0.055 (0.048–0.068) | 0.040 | 0.37 |
| Baseline Hb, g/L (Median, IQR) |
149 (139–156) |
149 (141–156) |
145 (136–153) |
147 (139–158) | 0.27 | 0.74 |
| Day of Treatment Hb, g/L (Mean, SD) |
139 (12.09) |
140 (11.81) |
136 (16.11) |
140 (12.61) | 0.22 | 0.57 |
| Nadir Hb, g/L (Median, IQR) |
132 (123–140) |
132 (123–140) |
127 (110–135) |
129 (121–140) | 0.024 | 0.22 |
| Hb Fractional Fall, % (Median, IQR) |
10.6 (7.9–13.8) |
10.3 (7.8–13.3) |
14.8 (11.8–15.9) |
11.7 (8.9–14.5) | 0.001 | 0.07 |
| Day Post Treatment of Hb Nadir (Median, IQR) |
12 (5–21) |
12 (5–21) |
15 (7–22) |
8 (7–15) | 0.66 | 0.11 |
| Day Post Treatment of return to baseline Hb (Median, IQR) |
28 b (22–37) |
28 b (22–37) | c |
20 (18–25) | c | < 0.0001 |
| % Contribution of pre-treatment Hb drop to total drop in Hb (Median, IQR) |
55 (23–78) |
55 (24–78) |
40 (11–76) |
45 (27–56) | 0.45 | 0.020 |
| Baseline reticulocyte count, 109/L (Median, IQR) |
55d (44–68) |
54 d (43–68) |
58 (49–76) |
58 (46–74) | 0.33 | 0.34 |
| Maximum post-treatment reticulocyte count, 109/L (Median, IQR) |
68d (54–90) |
66 d (53–89) |
84 (66–100) |
72 e (58–89) | 0.048 | 0.29 |
| Reticulocyte difference, 109/L (Median, IQR) |
12 f (3–28) |
11 g (1–27) |
20 (10–33) |
13 e (4–23) | 0.049 | 0.99 |