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Table 1 Summary of haematology and parasite data

From: Haematological response in experimental human Plasmodium falciparum and Plasmodium vivax malaria

  Pf all (n = 269) Pf 3D7 (n = 254) Pf K13 (n = 15) P. vivax (n = 46) P-value
(3D7 vs K13)
P-value
(Pf all vs
P. vivax)
Age, Years (Median, IQR) 24
(22–28)
24
(22–28)
23
(21–27)
24
(21–31)
0.38 0.87
Male Sex, n (%) 197 (73) 188 (74) 9 (60) 30 (65) 0.23 0.26
PPPre, Parasites/mL (Median, IQR) 10,277
(3566–27,815)
9,008
(3341–21,798)
71,427
(33,327–180,218)
34,840
(13,302–77,064)
 < 0.0001  < 0.0001
PP, Parasites/mL (Median, IQR) 20,218
(8350–55,570)
18,240
(7901–49,995)
132,160
(69,160–309,057)
53,696
(15,934–102,635)
 < 0.0001 0.0006
TPBPre, Parasites/mL (Median, IQR) 30,223 a
(14,320–90,970)
28,366 a
(12,637–75,571)
410,274 a
(166,853–1,106,184)
31,345
(12,264–67,516)
 < 0.0001 0.38
PRR (Median, IQR) 0.058
(0.045–0.081)
0.060
(0.045–0.082)
0.051
(0.045–0.055)
0.055
(0.048–0.068)
0.040 0.37
Baseline Hb, g/L (Median, IQR) 149
(139–156)
149
(141–156)
145
(136–153)
147
(139–158)
0.27 0.74
Day of Treatment Hb, g/L (Mean, SD) 139
(12.09)
140
(11.81)
136
(16.11)
140
(12.61)
0.22 0.57
Nadir Hb, g/L (Median, IQR) 132
(123–140)
132
(123–140)
127
(110–135)
129
(121–140)
0.024 0.22
Hb Fractional Fall, % (Median, IQR) 10.6
(7.9–13.8)
10.3
(7.8–13.3)
14.8
(11.8–15.9)
11.7
(8.9–14.5)
0.001 0.07
Day Post Treatment of Hb Nadir (Median, IQR) 12
(5–21)
12
(5–21)
15
(7–22)
8
(7–15)
0.66 0.11
Day Post Treatment of return to baseline Hb (Median, IQR) 28 b
(22–37)
28 b
(22–37)
c 20
(18–25)
c  < 0.0001
% Contribution of pre-treatment Hb drop to total drop in Hb (Median, IQR) 55
(23–78)
55
(24–78)
40
(11–76)
45
(27–56)
0.45 0.020
Baseline reticulocyte count, 109/L (Median, IQR) 55d
(44–68)
54 d
(43–68)
58
(49–76)
58
(46–74)
0.33 0.34
Maximum post-treatment reticulocyte count, 109/L (Median, IQR) 68d
(54–90)
66 d
(53–89)
84
(66–100)
72 e
(58–89)
0.048 0.29
Reticulocyte difference, 109/L (Median, IQR) 12 f
(3–28)
11 g
(1–27)
20
(10–33)
13 e
(4–23)
0.049 0.99
  1. n-number of participants; IQR- interquartile range; PP- peak parasitaemia; PPPre- pre-treatment peak parasitaemia; TPBPre- pre-treatment total parasite burden, determined using the AUC of the 18S qPCR data from day 4 until the time of treatment; PRR- parasite reduction ratio
  2. aThe TPBPre for the P. falciparum groups has been adjusted by a factor of 25% to account for sequestered parasites [50]; bPf all n = 267 and Pf3D7 n = 252 due to 2 participants not reaching haemoglobin baseline; cnone of the PfK13 participants’ haemoglobin returned to baseline; dPf all n = 254 and Pf3D7 n = 239; en = 44; fn = 246; gn = 231; Mann–Whitney test used unless otherwise stated