Table 2 Haemoglobin parameters in participants inoculated with Pf 3D7 who did not recrudesce, according to drug treatment
From: Haematological response in experimental human Plasmodium falciparum and Plasmodium vivax malaria
|
Pf3D7 (n = 168) Drugs (n) |
Nadir, g/L (median, IQR) |
Fractional Fall (%, median, IQR) |
Day post treatment of Hb Nadir (median, IQR) |
|---|---|---|---|
| ACT-451840 (1) | 136 | 9.33 | 9 |
| DSM265 (12) |
135 (130–141) |
10.9 (10.4–12.9) |
21 (14–23) |
| DSM265 + Artefenomel (7) |
115 (114–139) |
10.6 (6.1–11.6) |
21 (20–28) |
| Ferroquine (8) |
129 (118–133) |
11.3 (9.3–12.8) |
20 (18–21) |
| Griseofulvin (3) |
140 (136–146) |
8.5 (6.8–9.3) |
11 (4–20) |
| Cipargamin (4) |
139 (133–144) |
10.0 (8.0–13.0) |
20 (12–23) |
| M5717 (20) |
136 (132–142) |
10.6 (8.5–12.9) |
10 (6–14) |
| MMV048 (13) |
138 (131–143) |
11.4 (8.4–14.2) |
9 (8–12) |
| Mefloquine (22) |
127 (120–139) |
9.1 (7.9–14.7) |
4 (0–9) |
| Artefenomel (16) |
125 (119–139) |
8.6 (7.5–9.7) |
8 (1–21) |
| Artefenomel + Piperaquine (21) |
132 (127–140) |
9.1 (7.0–13.2) |
14 (0–27) |
| Piperaquine (23) |
129 (120–140) |
10.8 (6.3–13.0) |
19 (0–23) |
| Piperaquine + Primaquine (2) | 127–138 | 4.2–13.0 | 7–20 |
| SJ733 (10) |
136 (130–140) |
9.8 (8.3–11.6) |
12 (10–20) |
| ZY-19849 (6) |
128 (122–137) |
10.9 (5.5–11.6) |
7 (3–8) |