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Table 2 Haemoglobin parameters in participants inoculated with Pf 3D7 who did not recrudesce, according to drug treatment

From: Haematological response in experimental human Plasmodium falciparum and Plasmodium vivax malaria

Pf3D7 (n = 168)
Drugs (n)
Nadir, g/L
(median, IQR)
Fractional Fall
(%, median, IQR)
Day post treatment of Hb Nadir
(median, IQR)
ACT-451840 (1) 136 9.33 9
DSM265 (12) 135
(130–141)
10.9
(10.4–12.9)
21
(14–23)
DSM265 + Artefenomel (7) 115
(114–139)
10.6
(6.1–11.6)
21
(20–28)
Ferroquine (8) 129
(118–133)
11.3
(9.3–12.8)
20
(18–21)
Griseofulvin (3) 140
(136–146)
8.5
(6.8–9.3)
11
(4–20)
Cipargamin (4) 139
(133–144)
10.0
(8.0–13.0)
20
(12–23)
M5717 (20) 136
(132–142)
10.6
(8.5–12.9)
10
(6–14)
MMV048 (13) 138
(131–143)
11.4
(8.4–14.2)
9
(8–12)
Mefloquine (22) 127
(120–139)
9.1
(7.9–14.7)
4
(0–9)
Artefenomel (16) 125
(119–139)
8.6
(7.5–9.7)
8
(1–21)
Artefenomel + Piperaquine (21) 132
(127–140)
9.1
(7.0–13.2)
14
(0–27)
Piperaquine (23) 129
(120–140)
10.8
(6.3–13.0)
19
(0–23)
Piperaquine + Primaquine (2) 127–138 4.2–13.0 7–20
SJ733 (10) 136
(130–140)
9.8
(8.3–11.6)
12
(10–20)
ZY-19849 (6) 128
(122–137)
10.9
(5.5–11.6)
7
(3–8)
  1. n number of participants, IQR interquartile range