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Fig. 4 | Malaria Journal

Fig. 4

From: The presence of circulating antibody secreting cells and long-lived memory B cell responses to reticulocyte binding protein 1a in Plasmodium vivax patients

Fig. 4

Responses of MBC subset and plasmablasts/plasma cells during acute malaria. a The antibody responses to PvRBP1a in acute patients (AC, n  = 20) and healthy controls (HC, n  = 12) were detected using an indirect ELISA. b Gating scheme for MBC subset and plasmablast/plasma cell phenotyping by flow cytometric analysis. Activated MBCs (CD19+CD21−CD27+), atypical MBCs (CD19+CD21−CD27−), classical MBCs (CD19+CD21+CD27+), naïve B cells (CD19+CD21+CD27−) and plasmablasts/plasma cells (CD19+CD27hiCD38hi). c The proportion of activated MBCs, atypical MBCs, classical MBCs, naïve B cells and plasmablasts/plasma cells detected in acute patients, high responders (HR, n  = 4) and low responders (LR, n  = 16) compared to healthy controls (HC, n  = 12). d The proportion of switched (IgM−IgD− and IgM+ only) or unswitched (IgM+IgD+) MBC subpopulations were detected among activated and atypical MBCs in the HR group. The horizontal line represents mean values  ±  SEM. ****P  < 0.0001. HR high responders; LR low responders; NR non-responders

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Malaria Journal

ISSN: 1475-2875

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