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Fig. 1 | Malaria Journal

Fig. 1

From: How radical is radical cure? Site-specific biases in clinical trials underestimate the effect of radical cure on Plasmodium vivax hypnozoites

Fig. 1

Schematic of potential infection outcomes during trial follow-up. Participants are enrolled in the trial and initially harbour hypnozoite broods (coloured squares). The colours represent the genetic identity of each hypnozoite brood. Hypnozoite broods are cleared (unfilled dotted squares) with 8-aminoquinoline treatment according to the per-hypnozoite brood probability of clearance. Treatment with an 8-aminoquinoline provides each participant with a period of prophylaxis during which reinfections (solid line) and relapses (dotted line) are suppressed. Following prophylaxis, trial participants can experience re-infections and relapses, and these re-infections and relapses may be detected during the remainder of follow-up. Only relapses that arise from the activation of hypnozoite broods that were present before 8-aminoquinoline treatment reflect the per-hypnozoite brood clearance probability

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