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Fig. 6 | Malaria Journal

Fig. 6

From: How radical is radical cure? Site-specific biases in clinical trials underestimate the effect of radical cure on Plasmodium vivax hypnozoites

Fig. 6

Effect of parasite genotyping on efficacy estimates. The impact of genotyping recurrent infections to estimate the efficacy of radical cure is shown for different sensitivities and specificities of the genotyping method across a range of EIRs. Sensitivity of the genotyping method is the probability of correctly identifying a relapse associated with hypnozoites acquired prior to treatment, and specificity of the genotyping method is the probability of correctly identifying other recurrent infections. For a given EIR, the vertical panels correspond to the specificity of the genotyping method, and the colours of the points within a given panel denote the sensitivity of the genotyping method. Each point represents the median of 200 simulations, and each bar is the interquartile range. The dotted line is the clearance probability simulated in each trial

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