Fig. 3

Dissecting the effects of the four uAUGs in R[WT]. uAUGs were found to have a generally repressive effect on TE that can be dependent on the presence each other. Graphed for each is the average and SEM of log₂(each experimental value normalized to experimental R[WT] mean). The dotted line marks the average log₂(R[Δ1Δ2Δ3Δ4] normalized to R[WT]). For each figure, to the left is a diagram of the sequences using the same annotations as Fig. 2C. To the right of the diagrams are the results for P. falciparum and human K562s. a The effect of removing all four uAUGs from R[WT]. b The effect of retaining a single uAUG. c The effect of removing each uAUG individually. d The effect of removing two uAUGs in combination