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Table 4 The inhibitory effects of liposomes on the growth of Plasmodium falciparum parasites in infected human red blood cells (iRBC), expressed by the half maximal inhibition concentration (IC50)

From: Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria

Preparations P. falciparum 3D7 P. falciparum Dd2
Growth (n = 5) Inhibition (n = 5) Growth (n = 5) Inhibition (n = 5)
% IC50 mean ± SD (nM) % IC50 mean ± SD (nM)
Liposomal DQ
 F1   2.47 ± 0.23  
 F2   2.11 ± 0.52  
 F5   0.91 ± 0.05   1.33 ± 0.14
 F8   1.67 ± 0.04   1.12 ± 0.11
DQ in DMSO   1.63 ± 0.13   1.57 ± 0.49
Chloroquine   23.75 ± 0.06   184.8 ± 16.24
Artemisinin   16.44 ± 5.80   18.53 ± 0.50
Saline 100 ± 0.00   100 ± 0.00  
Liposomes
 F5 (no DQ) 100.46 ± 4.66   95.81 ± 4.95  
 F8 (no DQ) 101.46 ± 4.78   99.22 ± 4.17  
  1. Each preparation was described in the method section
  2. Means of results are calculated from three separate experiments run on different days
  3. DQ decoquinate, DMSO dimethylsulfoxide