Skip to main content

Table 4 The inhibitory effects of liposomes on the growth of Plasmodium falciparum parasites in infected human red blood cells (iRBC), expressed by the half maximal inhibition concentration (IC50)

From: Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria

Preparations

P. falciparum 3D7

P. falciparum Dd2

Growth (n = 5)

Inhibition (n = 5)

Growth (n = 5)

Inhibition (n = 5)

%

IC50 mean ± SD (nM)

%

IC50 mean ± SD (nM)

Liposomal DQ

 F1

 

2.47 ± 0.23

 

–

 F2

 

2.11 ± 0.52

 

–

 F5

 

0.91 ± 0.05

 

1.33 ± 0.14

 F8

 

1.67 ± 0.04

 

1.12 ± 0.11

DQ in DMSO

 

1.63 ± 0.13

 

1.57 ± 0.49

Chloroquine

 

23.75 ± 0.06

 

184.8 ± 16.24

Artemisinin

 

16.44 ± 5.80

 

18.53 ± 0.50

Saline

100 ± 0.00

 

100 ± 0.00

 

Liposomes

 F5 (no DQ)

100.46 ± 4.66

 

95.81 ± 4.95

 

 F8 (no DQ)

101.46 ± 4.78

 

99.22 ± 4.17

 
  1. Each preparation was described in the method section
  2. Means of results are calculated from three separate experiments run on different days
  3. DQ decoquinate, DMSO dimethylsulfoxide