From: Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria
Preparations | P. falciparum 3D7 | P. falciparum Dd2 | ||
---|---|---|---|---|
Growth (n = 5) | Inhibition (n = 5) | Growth (n = 5) | Inhibition (n = 5) | |
% | IC50 mean ± SD (nM) | % | IC50 mean ± SD (nM) | |
Liposomal DQ | ||||
 F1 |  | 2.47 ± 0.23 |  | – |
 F2 |  | 2.11 ± 0.52 |  | – |
 F5 |  | 0.91 ± 0.05 |  | 1.33 ± 0.14 |
 F8 |  | 1.67 ± 0.04 |  | 1.12 ± 0.11 |
DQ in DMSO |  | 1.63 ± 0.13 |  | 1.57 ± 0.49 |
Chloroquine |  | 23.75 ± 0.06 |  | 184.8 ± 16.24 |
Artemisinin |  | 16.44 ± 5.80 |  | 18.53 ± 0.50 |
Saline | 100 ± 0.00 |  | 100 ± 0.00 |  |
Liposomes | ||||
 F5 (no DQ) | 100.46 ± 4.66 |  | 95.81 ± 4.95 |  |
 F8 (no DQ) | 101.46 ± 4.78 |  | 99.22 ± 4.17 |  |