Table 4 The inhibitory effects of liposomes on the growth of Plasmodium falciparum parasites in infected human red blood cells (iRBC), expressed by the half maximal inhibition concentration (IC50)
From: Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria
| Preparations | P. falciparum 3D7 | P. falciparum Dd2 | ||
|---|---|---|---|---|
| Growth (n = 5) | Inhibition (n = 5) | Growth (n = 5) | Inhibition (n = 5) | |
| % | IC50 mean ± SD (nM) | % | IC50 mean ± SD (nM) | |
| Liposomal DQ | ||||
| F1 | 2.47 ± 0.23 | – | ||
| F2 | 2.11 ± 0.52 | – | ||
| F5 | 0.91 ± 0.05 | 1.33 ± 0.14 | ||
| F8 | 1.67 ± 0.04 | 1.12 ± 0.11 | ||
| DQ in DMSO | 1.63 ± 0.13 | 1.57 ± 0.49 | ||
| Chloroquine | 23.75 ± 0.06 | 184.8 ± 16.24 | ||
| Artemisinin | 16.44 ± 5.80 | 18.53 ± 0.50 | ||
| Saline | 100 ± 0.00 | 100 ± 0.00 | ||
| Liposomes | ||||
| F5 (no DQ) | 100.46 ± 4.66 | 95.81 ± 4.95 | ||
| F8 (no DQ) | 101.46 ± 4.78 | 99.22 ± 4.17 | ||