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Table 6 Pharmacokinetic evaluations of DQ liposomes at the dose of 10 mg/kg (n = 4) administered to Sprague–Dawley rats by intravenous injection (IV)

From: Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria

Parameters

Unit

Mean

SD

AUC0−t

µg/l

9733.08

1418.47

MRT0−t

h

4.53

0.77

t1/2

h

4.32

0.88

Vz

l/kg

6.60

2.50

CL

l/h/kg

1.04

0.16

Cmax

µg/l

10,147.02

3116

  1. AUC area under the curve, MRT mean residence time, t1/2 elimination half-life, Vz volume of distribution, CL plasma clearance, Cmax maximal concentration
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Malaria Journal

ISSN: 1475-2875

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