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Table 6 Pharmacokinetic evaluations of DQ liposomes at the dose of 10 mg/kg (n = 4) administered to Sprague–Dawley rats by intravenous injection (IV)

From: Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria

Parameters Unit Mean SD
AUC0−t µg/l 9733.08 1418.47
MRT0−t h 4.53 0.77
t1/2 h 4.32 0.88
Vz l/kg 6.60 2.50
CL l/h/kg 1.04 0.16
Cmax µg/l 10,147.02 3116
  1. AUC area under the curve, MRT mean residence time, t1/2 elimination half-life, Vz volume of distribution, CL plasma clearance, Cmax maximal concentration