Table 2 Other metabolites formed by PQ enantiomers as observed in different mouse tissues
From: Comparative pharmacokinetics and tissue distribution of primaquine enantiomers in mice
Mass (M + 1) | Retention time (min) | Putative identity | Key findings |
|---|---|---|---|
274.1544 | 2.35 | Hydroxylation and quinone-imine formation | Formed from both enantiomers, found only in the plasma |
332.1604 | 7.7 | Acetylated dihydroxy-PQ quinone-imine | Formed from RPQ and found in plasma and liver |
422.1929 | 4.9 | Glycosylated primaquine | Higher amount formed from SPQ than RPQ; found in the plasma and liver |
436.1992 | 2.17 | Primaquine glucuronide | Present only in the plasma with no remarkable enantiomeric difference in the profiles |
452.2027 | 1.9 | Hydroxy-primaquine glucuronide | Formed only from the SPQ enantiomer and found only in the in the plasma |
452.2027 | 9.26 | Hydroxy-primaquine glucuronide | Formed from both enantiomers and found in the liver, RBC, kidneys and lungs. No remarkable enantioselectivity |
480.1989 | 7.9 | Primaquine-N-carbamoyl glucuronide | Formed from both enantiomers; found only in the plasma |