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Table 3 Frequencies of molecular markers of resistance SP and AQ by individual PCR analysis at baseline and 2 and 3 years post-SMC

From: Effect of three years’ seasonal malaria chemoprevention on molecular markers of resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine and amodiaquine in Ouelessebougou, Mali

 

August 2014 Baseline

July 2016 Received 2 years of SMC

Dec 2016 Received 3 years post-SMC

   

n/N

%

n/N

%

n/N

%

p#

p##

p###

Pfdhfr C59R

81/82

98.8

46/49

93.9

52/52

100.0

0.147

1

0.089

Pfdhps A437G

73/98

74.5

18/57

31.6

42/65

64.6

 < 0.001

0.219

0.000

Pfdhps K540E

4/99

4.0

2/57

3.5

1/70

1.4

1.000

0.405

0.626

Pfmdr1 N86Y

5/89

5.6

5/51

9.8

11/59

18.6

0.497

0.016

0.050

Pfcrt K76T

62/87

71.3

46/57

80.7

31/46

67.4

0.240

0.693

0.272

  1. N, number of samples analyzed; n, number of mutations detected
  2. p# = baseline versus 2 years of SMC
  3. p## = baseline versus 3 years of SMC
  4. p### = comparison of baseline, 2 years of SMC and 3 years of SMC
  5. Baseline (pre-SMC): children who never received SMC
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Malaria Journal

ISSN: 1475-2875

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