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Table 1 A summary of promising quinine dose regimens used in clinical studies during 1982 to 2013 in vulnerable subjects

From: Clinical pharmacokinetics of quinine and its relationship with treatment outcomes in children, pregnant women, and elderly patients, with uncomplicated and complicated malaria: a systematic review

Population

Dose regimen

Required dose adjustment

Uncomplicated malaria

Complicated malaria

Children

8–12 mg base/kg iv q8h for 7d

8–12 mg base/kg im q12h for 7d

N

Y*

Pregnant women

8.3 mg base/kg PO q8h for 7d

Loading dose of 16.7 mg base/kg iv over 4 h, followed by 8.3 mg base/kg q8h

Y

-

-

Y

Elderly

8.3 mg base/kg PO q8h for 7d

Loading dose of 16.7 mg base/kg iv over 4 h, followed by 8.3 mg/kg q8h until patients can swallow then complete oral dose regimen

N**

N**

N**

N**

  1. Iv intravenous infusion, im intramuscular injection, PO per oral
  2. *No standard regimen of quinine administration reported for complicated malaria; **the results were estimated from a single dose of 600 mg of quinine administration in elderly