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Fig. 4 | Malaria Journal

Fig. 4

From: Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice

Fig. 4

SJ733 arrests maturation and replication in ring-stage parasites. A Schematic showing that 7 h after Gen0 pRBC adoptive transfer into mice (n = 5/group) and SJ733, artesunate or control saline treatment, peripheral blood was cultured ex vivo to determine the capacity of remaining drug-exposed Gen0 pRBC to mature and undergo schizogony. B Representative FACS plots depicting schizogony with Hoechst33342 staining in Gen0 pRBC over 15 h of culture, starting at 7 h post-in vivo drug exposure. C Summary graph for individual mice, showing percentage of Gen0 pRBC that were schizonts before and after ex vivo culture. D A logistic growth model fit to saline-treated controls (black), 50 mg/kg, artesunate (blue), and 200 mg/kg, SJ733 (red)-treated infections. The model was used to estimate the number of viable parasites remaining 24 h after treatment

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