Fig. 5
Pyronaridine arrests maturation in ring-stages and modestly increases pRBC removal. A Summary of Gen0 and Gen1+ pRBC dynamics expressed as a percentage of total RBC after single dose treatment with pyronaridine, artesunate or control saline (n = 5 mice/group). B Summary dynamics for Gen0 rings, trophozoites and schizonts expressed as a percentage of all RBC. C Representative FACS plots depicting schizogony with Hoechst staining, and GFP expression in Gen0 pRBC over 15 h of culture, starting at 7 h post-in vivo drug exposure. D Summary graph for individual mice, showing percentage of Gen0 pRBC that were schizonts before and after ex vivo culture. Error bars represent the standard the standard error of the mean