Table 3 Haematological changes between days 0 and 7 based on CYP2D6 and G6PD status
Haematological changes based on CYP2D6 status | |||
|---|---|---|---|
A: absolute haemoglobin reduction | |||
Day of follow-up | Reduced CYP2D6 | Normal CYP2D6 | Statistical test |
Mean (95%CI) | Mean (95%CI) | ||
Day 1 | 0.86 (0.50–1.22) | 0.67 (0.49–0.86) | t = 1.034, p = 0.303 |
Day 2 | 1.28 (0.89–1.65) | 1.21 (1.01–1.42) | t = 0.383, p = 0.703 |
Day 3 | 1.50 (1.10–1.90) | 1.51 (1.31–1.71) | t = 0.012 p = 0.990 |
Day 7 | 1.16 (0.70–1.62) | 1.05 (0.79–1.28) | t = 0.428, p = 0.669 |
B: relative % haemoglobin reduction | |||
|---|---|---|---|
Day of follow-up | |||
Day 1 | 7.65 (4.24–10.62) | 6.12 (4.16–7.55) | t = 0.834, p = 0.406 |
Day 2 | 11.15 (7.84–14.13) | 11.02 (8.97–12.64) | t = 0.069, p = 0.945 |
Day 3 | 13.12 (9.51–16.44) | 13.80 (11.81–15.43) | t = − 0.347, p = 0.729 |
Day 7 | 9.82 (5.96–13.68) | 9.19 (6.86–11.30) | t = 0.270, p = 0.788 |
Haematological changes based on G6PD status | ||||
|---|---|---|---|---|
A: mean absolute haemoglobin reduction | ||||
Day of follow-up | G6PD deficient, mean (95%CI) | G6PD Normal, mean (95%CI) | G6PD Heterozygous mean (95%CI) | Statistical Test |
Day 1 | 0.94 (0.52–1.35) | 0.69 (0.52–0.88) | 0.72 (0.16–1.29) | F = 0.463, p = 0.630 |
Day 2 | 1.27 (0.83–1.71) | 1.24 (1.03–1.45) | 1.19 (0.66–1.72) | F = 0.028, p = 0.972 |
Day 3 | 1.82 (1.32–2.32) | 1.48 (1.30–1.67) | 1.47 (0.76–2.18) | F = 0.838, p = 0.435 |
Day 7 | 1.55 (1.02–2.08) | 1.05 (0.82–1.28) | 0.75 (− 0.04 to 1.53) | F = 2.063, p = 0.131 |
B: mean relative % haemoglobin reduction | ||||
|---|---|---|---|---|
Day of follow-up | ||||
Day 1 | 8.35 (4.58–12.12) | 6.12 (4.44–7.81) | 6.43 (1.20–11.66) | F = 0.438, p = 0.618 |
Day 2 | 11.13 (7.28–14.98) | 11.07 (9.25–12.89) | 10.82 (5.90–15.73) | F = 0.007, p = 0.993 |
Day 3 | 16.46 (12.0–20.92) | 13.27 (11.63–14.9) | 13.10 (6.39–19.81) | F = 0.928, p = 0.398 |
Day 7 | 13.57 (9.39–17.75) | 9.06 (6.95–11.17) | 6.57 (− 0.87 to 14.01) | F = 1.896, p = 0.154 |