Table 4 Haematological changes based on CYP2D6 and G6PD status
Normal for CYP2D6 and G6PD status | Reduced CYP2D6 only | G6PD deficiency only | Both reduced CYP2D6 and G6PD deficiency | Test, p-value | |
|---|---|---|---|---|---|
Mean, 95% CI | Mean, 95% CI | Mean, 95% CI | Mean, 95% CI | ||
Mean absolute Hb reduction | |||||
Day of follow-up | |||||
Day 1 | 0.64 (0.45–0.83) | 0.99 (0.53–1.46) | 1.19 (0.55–1.83) | 0.62 (0.05–1.19) | F = 1.661, p = 0.178 |
Day 2 | 1.19 (0.99–1.41) | 1.40 (0.91–1.88) | 1.45 (0.69–2.20) | 1.06 (0.56–1.56) | F = 0.422, p = 0.737 |
Day 3 | 1.47 (1.27–1.67) | 1.55 (1.04–2.07) | 2.12 (1.27–2.97) | 1.46 (0.92–1.99) | F = 1.214, p = 0.307 |
Day 7 | 0.96 (0.72) | 1.18 (0.58–1.79) | 1.92 (1.11–2.72) | 1.10 (0.41–1.79) | F = 1.932, p = 0.127 |
Mean relative% Hb reduction | |||||
Day of follow-up | |||||
Day 1 | 5.73 (3.95–7.51) | 8.23 (4.35–12.11) | 10.17 (4.80–15.55) | 6.12 (-0.02–12.26) | F = 1.102, p = 350 |
Day 2 | 10.89 (8.99–12.78) | 11.70 (7.63–15.78) | 12.34 (5.51–19.13) | 9.68 (5.61–13.75) | F = 0.165, p = 0.920 |
Day 3 | 13.30 (11.46–15.13) | 12.98 (8.48–17.48) | 18.87 (11.20–26.55) | 13.51 (8.99–18.02) | F = 1.113, p = 0.346 |
Day 7 | 8.45 (6.15–10.73) | 9.79 (4.62–14.96) | 16.56 (10.25–22.86) | 9.91 (4.37–15.45) | F = 1.624, p = 0.186 |
Anaemic | |||||
Day of follow-up | |||||
Day 3, n (%) | 91.2% (103/113) | 87.5% (21/24) | 81.8% (9/11) | 88.9% (8/9) | X2 = 1.138, p = 0.768 |
Day 7, n (%) | 83.2% (94/113) | 66.7% (16/24) | 100.0% (11/11) | 100.0% (9/9) | X2 = 8.55, p = 0.036 |