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Table 1 Overall geomean and sensitivity of TBS, uRDT, and cRDT compared to the qPCR method

From: Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection of low-density Plasmodium falciparum infections during a controlled human malaria infection study in Equatorial Guinea

Diagnostic test

TBS (+)

TBS (−)

uRDT (+)

uRDT (−)

cRDT (+)

cRDT (−)

Total

PCR Pf (+)

24

99

21

102

10

113

123

PCR Pf (−)

0

156

0

156

0

156

156

Total

24

255

21

258

10

269

279

Range of positive samples (p/µL by qPCR)

5.9–603.8

0.8–603.8

2.6–603.8

 

Geomean of positive samples (p/µL by qPCR)

97.6

103.4

149.4

 

Sensitivity (%)

19.5% (13.1–27.8)

17.1% (11.1–25.1)

8.1% (4.2–14.8)

 
  1. Number of positive and negative samples, overall geomean and sensitivity of TBS, uRDT, and cRDT compared to the reference qPCR method. All cases were low parasite density infections that occurred during CHMI. Parasite densities of positive samples by qPCR ranged from 0.14–603.84 p/µL