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Table 2 Overall geomean and sensitivity of uRDT and cRDT compared to the TBS method

From: Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection of low-density Plasmodium falciparum infections during a controlled human malaria infection study in Equatorial Guinea

Diagnostic test

uRDT (+)

uRDT (−)

cRDT (+)

cRDT (−)

Total

TBS (+)

13

11

9

15

24

TBS (−)

8

247

1

254

255

Total

21

258

10

269

279

Geomean of positive samples (p/µL by TBS)

20.6

30.2

 

Sensitivity (%)

54.2% (33.2–73.8)

37.5% (19.6–59.2)

 
  1. Overall geomean, sensitivity and number of positive and negative samples of uRDT, and cRDT compared to TBS. All cases occurred during CHMI. Parasite densities of positive samples by TBS ranged from 3.7 to 201.8 p/µL