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Table 5 Comparison of uRDT and cRDT sensitivity stratified by parasite density (p/µL) as determined by TBS

From: Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection of low-density Plasmodium falciparum infections during a controlled human malaria infection study in Equatorial Guinea

Group density (p/µL)

# samples TBS (+) (reference)

uRDT (+)

uRDT sensitivity (95% CI)

cRDT (+)

cRDT sensitivity (95% CI)

< 1

0

0

–

0

–

1–10

15

5

33% (12–62)

2

13% (2–40)

11–50

5

5

100% (48–100)

4

80% (28–99)

51–100

2

2

100% (16–100)

2

100% (16–100)

> 100

2

1

50% (1–99)

1

50% (1–99)

  1. Number of samples and sensitivity of uRDT and cRDT stratified by parasite density (p/µL). Diagnostic methods are compared to TBS as reference and all cases were low parasite density samples that occurred during CHMI follow-up