Table 4 28-day PCR corrected treatment outcome: 2/3 algorithm
PCR adjusted Outcome | Artesunate–amodiaquine | Aretemether-lumefantrine | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Bensonville (n = 91) | Saclepea (n = 89) | Overall (n = 180) | Kakata (N = 89) | Sinje (N = 90) | Overall (N = 179) | |||||
n (%) | CI 95% | n (%) | 95% CI | % (CI 95%) | n (%) | 95% CI | n (%) | 95% CI | % (CI 95%) | |
LCFa | 1 (1.8) | 0.0–9.4 | 2 (2.4) | 0.3–8.4 | 2.1 (0.4–6.1 | 0 | 0.0–4.5 | 0 (0) | 0.0–4.1 | 0 (0.0–2.2) |
LPFb | 10 (17.5) | 8.7–29.9 | 5 (6.0) | 2.0–13.5 | 10.7 (6.1–17.1) | 1 (1.3) | 0.0–6.8 | 0 (0) | 0.0–4.1 | 0.6 (0.0–3.3) |
ACPRc | 46 (80.7) | 68.1–90.0 | 76 (91.6) | 83.4–96.5 | 87.1 (80.4–92.2) | 79 (98.8) | 93.2–100 | 88 (100) | 95.9–100 | 99.4 (96.7–100) |
Total per-protocol | 57 | 83 | 140 | 80 | 88 | 168 | ||||
Withdrawn/lost: | 19 (20.9) | 1 (1.1) | 20 (11.1) | 5 (5.6) | 2 (2.2) | 7 (3.9) | ||||
Re-infection | 13 | 5 | 18 | 4 | 0 | 4 | ||||
PCR NId | 2 | 0 | 2 | 0 | 0 | 0 | ||||
eKM cure rate | 84.1 | 73.0–90.9 | 91.8 | 83.6–96.0 | 88.4 (82.2–92.5) | 98.8 | 100 | 99.4 (95.9–99.9) | ||