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Table 7 dhfr and dhps alleles observed in P. falciparum obtained from blood samples collected prior antimalarial treatment

From: Artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers

 

Bensonville (n = 91)

Saclepea (n = 89)

Kakata (n = 89)

Sinje Town (n = 90)

Total (n = 359)

 

n

%

n

%

n

%

n

%

N

%

dhfr

WT

14

15.6%

5

5.6%

9

10.1%

24

26.7%

52

14.5%

108 N

43

47.8%

25

28.1%

32

36.0%

30

33.3%

130

36.3%

51I/59R/108 N

33

36.7%

59

66.3%

48

53.9%

36

40.0%

176

49.2%

Total*

90

100.0%

89

100.0%

89

100.0%

90

100.0%

358

100.0%

dhps

WT

26

29.2%

43

48.3%

52

58.4%

50

55.6%

171

47.9%

436A

7

7.9%

13

14.6%

12

13.5%

19

21.1%

51

14.3%

437G

15

16.9%

0

0

1

1.1%

1

1.1%

17

4.8%

K540E

15

16.9%

15

16.9%

15

16.9%

12

13.3%

57

16.0%

A613S

2

2.2%

3

3.4%

0

0

4

4.4%

9

2.5%

436A/437G

17

19.1%

8

9.0%

3

3.4%

4

4.4%

32

9.0%

436A/613S

0

0

4

4.5%

4

4.5%

0

0

8

2.2%

S436A/K540E

1

1.1%

0

0

0

0

0

0

1

0.3%

437G/581G

1

1.1%

0

0

1

1.1%

0

0

2

0.6%

437G/540E

1

1.1%

0

0

0

0

0

0

1

0.3%

436A/437G/540E

1

1.1%

0

0

0

0

0

0

1

0.3%

436A/437G/613S

2

2.2%

0

0

0

0

0

0

2

0.6%

436A/581G/613S

0

0

0

0

1

1.1%

0

0

1

0.3%

436A/437G/581G/613S

1

1.1%

3

3.4%

0

0

0

0

4

1.1%

Total **

89

100.0%

89

100.0%

89

100.0%

90

100.0%

357

100.0%

  1. *One sample from Bensonville gave not interpretable data for dhfr sequence. ** two samples from Bensonville gave not interpretable data for dhps sequence