Table 8 dhfr/dhps haplotypes observed in P. falciparum obtained from blood samples collected prior antimalarial treatment
Haplotype | Bensonville (n = 91) | Saclepea (n = 89) | Kakata (n = 89) | Sinje Town (n = 90) | Total (n = 359) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | % | n | % | n | % | n | % | N | % | |||
Combined | dhfr | dhps | ||||||||||
Wild type | WT | WT | 5 | 5.6% | 1 | 1.1% | 7 | 7.9% | 15 | 16.7% | 28 | 7.8% |
Single mutant | WT | 436A | 0 | 0 | 1 | 1.1% | 0 | 0 | 4 | 4.4% | 5 | 1.4% |
WT | 437G | 2 | 2.2% | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.6% | |
WT | 613S | 1 | 1.1% | 0 | 0 | 0 | 0 | 1 | 1.1% | 2 | 0.6% | |
WT | K40E | 3 | 3.4% | 1 | 1.1% | 1 | 1.1% | 4 | 4.4% | 9 | 2.5% | |
108 N | WT | 9 | 10.1% | 8 | 9.0% | 21 | 23.6% | 15 | 16.7% | 53 | 14.8% | |
Double mutant | WT | 436A/437G | 3 | 3.4% | 2 | 2.2% | 0 | 0 | 0 | 0 | 5 | 1.4% |
108 N | 436A | 5 | 5.6% | 5 | 5.6% | 4 | 4.5% | 7 | 7.8% | 21 | 5.9% | |
108 N | 437G | 8 | 9.0% | 0 | 0 | 0 | 0 | 1 | 1.1% | 9 | 2.5% | |
108 N | 540E | 10 | 11.2% | 4 | 4.5% | 5 | 5.6% | 4 | 4.4% | 23 | 6.4% | |
108 N | 613S | 1 | 1.1% | 2 | 2.2% | 0 | 0 | 0 | 0 | 3 | 0.8% | |
Triple mutant | WT | S436A/A581G/A613S | 0 | 0 | 0 | 0 | 1 | 1.1% | 0 | 0 | 1 | 0.3% |
51I/59R/108 N | WT | 12 | 13.5% | 34 | 38.2% | 24 | 27.0% | 20 | 22.2% | 90 | 25.2% | |
108 N | 436A/437G | 8 | 9.0% | 2 | 2.2% | 0 | 0 | 3 | 3.3% | 13 | 3.6% | |
108 N | 436A/613S | 0 | 0 | 1 | 1.1% | 1 | 1.1% | 0 | 0 | 2 | 0.6% | |
108 N | 437G/581G | 1 | 1.1% | 0 | 0 | 1 | 1.1% | 0 | 0 | 2 | 0.6% | |
Quadruple mutant | 51I/59R/108 N | 436A | 2 | 2.2% | 7 | 7.9% | 8 | 9.0% | 8 | 8.9% | 25 | 7.0% |
51I/59R/108 N | 437G | 5 | 5.6% | 0 | 0 | 1 | 1.1% | 0 | 0 | 6 | 1.7% | |
51I/59R/108 N | 540E | 2 | 2.2% | 10 | 11.2% | 9 | 10.1% | 4 | 4.4% | 25 | 7.0% | |
51I/59R/108 N | 613S | 0 | 0 | 1 | 1.1% | 0 | 0 | 3 | 3.3% | 4 | 1.1% | |
Quintuple mutant | 51I/59R/108 N | 436A/437G | 6 | 6.7% | 4 | 4.5% | 3 | 3.4% | 1 | 1.1% | 14 | 3.9% |
51I/59R/108 N | 436A/540E | 1 | 1.1% | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.3% | |
51I/59R/108 N | 436A/613S | 0 | 0 | 3 | 3.4% | 3 | 3.4% | 0 | 0 | 6 | 1.7% | |
51I/59R/108 N | 437G/540E | 1 | 1.1% | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.3% | |
108 N | 437G/581G/613S | 0 | 0 | 0 | 0 | 3 | 3.4% | 0 | 0 | 3 | 0.8% | |
Sextuple mutant | 51I/59R/108 N | 436A/437G/613S | 2 | 2.2% | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.6% |
Septuple mutant | 51I/59R/108 N | 436A/437G/581G/613S | 1 | 1.1% | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.3% |
Total * | 89 | 100.0% | 89 | 100.0% | 89 | 100.0% | 90 | 100.0% | 357 | 100.0% | ||