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Table 3 In vitro susceptibility of P. falciparum, parental (B5), pfexo-modified (B5-rexo-E415G-B8) and adapted clinical parasites to dihydroartemisinin (DHA), artesunate (AS), mefloquine (MQ), quinine (QN), chloroquine (CQ), atovaquone (ATQ), lumefantrine (LUM), doxycycline (DOX), tafenoquine (TQ), cycloguanil (CYC), primaquine (PQ), proguanil (PG), and pyronaridine (PND). (mean ± SD, nM)

From: A single point mutation in the Plasmodium falciparum 3′–5′ exonuclease does not alter piperaquine susceptibility

Drug

IC50 (nM)

B5

B5-r exo-E415G-B8

ASAP-21

ASAP-168

P-value

DHA

9 ± 4

14 ± 6

5 ± 0.2

2 ± 1

0.1213

AS

7 ± 5

4 ± 1

3 ± 0.4

3 ± 1

–

MQ

161 ± 58

82 ± 37

61 ± 23

50 ± 20

0.0483

QN

546 ± 180

564 ± 165

71 ± 3

138 ± 32

0.0172,3

CQ

562 ± 218

416 ± 219

64 ± 12

256 ± 59

0.0172

ATQ

48 ± 38

114 ± 1

5 ± 0.6

4 ± 1

0.0171,2,3

LUM

10 ± 8

4 ± 1

2 ± 0.2

3 ± 1

–

DOX

13,523 ± 2337

14,649 ± 1071

8527 ± 349

10,920 ± 1061

0.0242

TQ

263 ± 143

315 ± 45

189 ± 13

274 ± 554

–

CYC

2063 ± 2703

705 ± 15

7183 ± 388

 N.D.

–

PQ

3094 ± 2015

6387 ± 218

5720 ± 1160

2458 ± 61

–

PG

12,522 ± 7247

23,816 ± 3786

2114 ± 243

3643 ± 473

0.0331

PND

28 ± 16

25 ± 4

50 ± 2

12 ± 6

0.0332

  1. P-value calculated by Mann–Whitney U Test
  2. 1,2,3Significant differences between data from B5-rexo-E415G-B8, ASAP-21, and ASAP-168 compared to B5 line, respectively
  3. N.D. for not determined
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Malaria Journal

ISSN: 1475-2875

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