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Table 3 Association of maternal iron status (ferritin) with malaria infection at antenatal enrolment and at delivery, Madang, Papua New Guinea, 2009–2013

From: Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women

Factor

aOR (95% CI)

P value

Enrolment

 Peripheral infectiona

  Iron deficiency

   Ferritin < 15 μg/L

0.50 (0.38, 0.66)

 < 0.001

   Ferritin ≥ 15 μg/L

Reference

 

  Log2(ferritin)

1.37 (1.23, 1.53)

 < 0.001

Delivery

 Peripheral infectiona

  Iron deficiency

   Ferritin < 15 μg/L

0.68 (0.46, 1.00)

0.050

   Ferritin ≥ 15 μg/L

Reference

 

  Log2(ferritin)

1.27 (1.10, 1.48)

0.001

 Placental infection (blood)a

  Iron deficiency

   Ferritin < 15 μg/L

0.66 (0.39, 1.14)

0.14

   Ferritin ≥ 15 μg/L

Reference

 

  Log2(ferritin)

1.22 (1.00, 1.49)

0.054

 Placental infection (histology)a

  Iron deficiency

   Active infection

0.91 (0.58, 1.43)

0.68

   Past infection

0.35 (0.24, 0.50)

 < 0.001

   No infection

Reference

 

  Log2(ferritin)

   Active infection

1.04 (0.88, 1.22)

0.64

   Past infection

1.65 (1.42, 1.91)

 < 0.001

   No infection

Reference

 
  1. Analyses adjusted for gravidity, maternal age, malaria chemoprevention regimen, rural location, and gestational age at ferritin measurement. Ferritin levels were adjusted for concurrent inflammation and peripheral malaria parasitaemia using the BRINDA (Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia) approach [36]
  2. aOR: adjusted odds ratio; CI: confidence interval
  3. aInclude 1,886, 1,886, 1,253 and 1,356 women with malaria infection data (Plasmodium falciparum, P. vivax) from peripheral blood at enrolment, peripheral blood at delivery, placental blood, and placental histology collected at delivery, respectively