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Table 5 Proteasomal cleavage of α- and η-CAs from Plasmodium spp.

From: A reverse vaccinology approach on transmembrane carbonic anhydrases from Plasmodium species as vaccine candidates for malaria prevention

CA class

HLA-A and -B alleles

Proteasome cleaved peptides

Scorea

α-CA

(group 1)

(W7JAI7)

HLA-A*24

509-IYFILFIFYNIVLF-522

1.25

HLA-A*11

399-STLPLCDENVSWKV-412

1.04

HLA-B*53

467-QVFPIQVLISSAIS-480

1.18

α-CA

(group 2)

(Q8IHW5)

HLA-A*24

585-IYFILFIFYNIVLF-598

1.25

HLA-A*11

476-STLPLCDENVSWKV-489

1.04

HLA-B*53

8-YPILLFYNVNVF-19

1.41

η-CA

(V7PFH4)

HLA-A*02

632-VYLIQGFPVQL-642

1.62

HLA-B*53

638-FPVQLLISSAL-648

1.42

  1. aHigh value predicts high cleavage efficiency (Range limit: 0.0–2.0)