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Table 2 The list and frequency of pvmdr-1 mutations in ROK army from 2016 to 2017

From: Single nucleotide polymorphism analysis of pvmdr-1 in Plasmodium vivax isolated from military personnel of Republic of Korea in 2016 and 2017

Mutations in the pvmdr-1 gene

No.(%) of mutated isolates

2016 (N = 20)

2017 (N = 53)

K44 (AAG-132-AAA)

4/20 (20%)

24/53 (45.2%)

L493 (TTA-1477-CTA)

5/20 (25%)

14/53 (26.4%)

T529 (ACA-1587-ACG)

15/20 (75%)

30/53 (56.6%)

Y541C (TAC-1622-TGC)

0/20 (0%)

1/53 (1.8%)

G698S (GGC-2092-AGC)

20/20 (100%)

53/53 (100%)

L845F (CTC-2533-TTC)

20/20 (100%)

53/53 (100%)

M908L (ATG-2722-CTG)

20/20 (100%)

53/53 (100%)

T958M (ACG-2873-ATG)

20/20 (100%)

53/53 (100%)

F1076L (TTT-3226-CTT)

20/20 (100%)

53/53 (100%)

E1233 (GAG-3699-GAA)

8/20 (40%)

30/53 (56.6%)

  1. Quintuple non-synonymous mutations (G689S, L845F, M908L, T958M, and F1076L) and synonymous mutations (K44, L493, T529, and E1233) were detected in specimens. Furthermore, a novel non-synonymous mutation (Y541C) was detected in 1 patient