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Table 2 Effects of anthracycline antibiotics on unwinding activity of PfDH-B and in vitro parasite growth

From: Inhibitory effects of anthracyclines on partially purified 5′–3′ DNA helicase of Plasmodium falciparum

Drugs

IC50 (μM)

PfDH-B

P. falciparum strain K1*

Aclarubicin

4.0

1.8 ± 0.75

Daunorubicin

7.5

2.5 ± 0.16

Doxorubicin

3.6

1.5 ± 0.21

Nogalamycin

3.1

0.1 ± 0.002

Chloroquine

ND

1.7 ± 1.68

  1. ND not done
  2. *The apparent IC50 value was determined from the concentration of the inhibitor sufficient to achieve 50% growth inhibition. The values are the mean (± standard deviation) obtained from a single assay of each drug in triplicate
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Malaria Journal

ISSN: 1475-2875

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