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Fig. 2 | Malaria Journal

Fig. 2

From: Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modelling study

Fig. 2

Classic and integral gene drive systems. A Classic gene drive system and possible alleles. Two types of resistant alleles, where the driver can no longer recognize the target site and there is no functional drive construct, are possible; the first type is a mutated, non-functional drive construct allele and the second type is a mutated target site allele without a drive construct. These two types of resistant alleles are considered as one group in our model. B Integral gene drive system and possible alleles. Analogous to the classic case, two types of resistant alleles, where the driver can no longer recognize the target site and there is no functional driver or effector gene, are possible. These two types of resistant alleles are again grouped together within our model. Two types of loss of function alleles, where a lethal mutation in an essential gene and target site leads to non viability, are also possible; the first type is a mutated essential gene allele containing an effector or driver construct and the second type is a mutated essential gene allele that does not contain an introduced effector or driver construct. As with the different types of resistant alleles, these two types of loss of function alleles are considered as one group within our model

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