Table 1 Classic gene drive system parameters
Parameter | Description | Default value | Range |
|---|---|---|---|
d | Drive efficiency and transmission rate | 1 | 0.9–1 |
u | Probability of resistance arising if drive transmission fails | 0.5 | – |
lne | Probability of complete construct loss during homing | 3E−4 | – |
sd | Fitness cost of target site disruption | 0 | – |
sne | Fitness cost of complete construct expression | 0 | 0–0.5 |
hd | Dominance coefficient for target site disruption | 0.5 | – |
hne | Dominance coefficient for complete construct expression | 0.5 | – |
hrc | Dominance coefficient for parasite refractoriness | 1 | – |
rc | Homozygous degree of parasite refractoriness | 1 | 0.5–1 |
rr0 | Initial population target site resistance frequency | 0 | 0–0.1 |