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Table 3 Namibia study participant characteristics and performance of PfHRP2 model with half-life of 4.5 days

From: The in-vivo dynamics of Plasmodium falciparum HRP2: implications for the use of rapid diagnostic tests in malaria elimination

ID

Characteristics

Model performance

Age

Sex

Estimated weight (kg)

Enrolment parasitaemia (p/mL) × 106

Enrolment PfHRP2 (pg/mL) × 106

Follow up duration (days)

Number (%) observations in predicted interval

RSS

RMSE

Predicted days above 800 pg/mL

Last day observed above 800 pg/mL

Predicted days above 80 pg/mL

Last day observed above 80 pg/mL

F1

24

Male

61

9.46

0.83

84

2 (14%)

10.77

0.877

44.9

56

59.9

63

F2

25

Male

62

2.88

0.33

63

5 (50%)

1.56

0.395

34.3

35

49.3

42

F3

25

Female

58

0.10

0.002

21

1 (25%)

0.41

0.320

14.1

14

29.1

F4

24

Male

61

22.61

0.40

56

6 (67%)

1.43

0.399

47.7

42

62.7

F5

25

Female

58

0.39

3.66

28

3 (60%)

5.57

1.055

23.3

21

38.3

F6

24

Female

56.5

49.35

10,931.8

77

4 (31%)

19.3

1.217

54.9

56

69.9

70

  1. Participant characteristics and model performance of the updated model with PfHRP2 half-life estimate of 4.5 days applied to 6 individuals aged between 23 and 27 years from the study in Namibia in participants with P. falciparum mono-infection
  2. RSS residual sum of squares, RMSE root mean standard error calculated on the mid-point of the minimum and maximum predicted PfHRP2 concentrations—no observations were observed below 80 pg/mL so the last day above the threshold of 80 pg/mL was not able to be reported