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Table 2 Genotypes and phenotypes frequencies of Duffy blood group among P. vivax infected patients in East Shewa, Ethiopia

From: Vivax malaria in Duffy-negative patients shows invariably low asexual parasitaemia: implication towards malaria control in Ethiopia

DbSNP

rs2814778

rs12075

rs34599082

rs13962

Predicted genotype

Predicted antigen

Phenotype

No. (%)

Nucleotide

c.1-67a

c.125b

c.265c

c.298d

Region

5′UTR

Exon 2

Exon 2

Exon 2

SNP (amino acid)

C

A(Asp42)

C(Arg89)

G(Ala100)

FY*BES/FY*BES or FY*02 N.01/FY*02 N.01

Fyes/Fyes

Fy(a − b −)

4 (2.9)

T

G(Gly42)

C(Arg89)

G(Ala100)

FY*A/FY*A or FY*01/FY*01

Fya

Fy(a + b −)

7 (5.1)

A(Asp42)

C(Arg89)

G(Ala100)

FY*B/FY*B or FY*02/FY*02

Fyb

Fy(a − b +)

6 (4.3)

G(Gly42)/A(Asp42)

C(Arg89)

G(Ala100)

FY*A/FY*B or FY*01/FY*02

Fya/Fyb

Fy(a + b +)

17 (12.3)

C/T

A(Asp42)

C(Arg89)

G(Ala100)

FY*B/FY*BES or FY*02/FY*02 N.01

Fyb/Fyes

Fy(a − b +)

67 (48.6)

A(Asp42)

C(Arg89)

A(Thr100)

FY*02/FY*02 N.01

Fyb/Fyes

Fy(a − b +)

1 (0.7)

A(Asp42)

C(Arg89)/T(Cys89)

G(Ala100)/A(Thr100)

FY*BES/FY*X or FY*02 W.01/FY*02 N.01

Fyx/Fyes

Fy(a − b +)

1 (0.7)

G(Gly42)/A(Asp42)

C(Arg89)

G(Ala100)

FY*A/FY*BES or FY*01/FY*02 N.01

Fya/Fyes

Fy(a + b −)

35 (25.4)

  1. NB: the nucleotide position (dbSNP) is based on NCBI data, UTR: untranslated region
  2. aThis polymorphism prevents expression of Fyb antigen in red blood cells
  3. bThis polymorphism predicts the expression of the Fya and Fyb antigens
  4. c,dThese polymorphisms determine weak expression of the Fyb antigen