Skip to main content

Table 3 Anti-malarial activity of compounds reported from Ethiopian medicinal plants

From: Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies

Plant Species Reported Compound (s) Plant Part (s) used IC50 or ED50 or Parasite suppression rate Antiplasmodial/Anti-malarial activity Strain of Plasmodium tested Safe dose to non-infected mice (mg/kg body weight) References
Embelia schimperi Embelin (1) Fruit 54.8% at 400 mg/kg/day Moderate Pb 2000 [96]
Aloe percrassa Microdontin A/B (2) Leave latex 61.4% at 400 mg/kg/day Good Pb NE [68]
  Aloin A/B (3) Leave latex 66.8% at 400 mg/kg/day     
Kniphofia foliosa Chryslandicin (4) Rhizome 2.1 and 1.5 μg/ml Very good Pb D6 and W2 respectively NE [97]
  10-Hydroxy-10 (chrysophanol-7’-yl)chrysophanol anthrone (5)   1.7 and 0.7 μg/ml     
  10-Methoxy-10-(chrysophanol-7’-yl)chrysophanol anthrone (6)   4.1 and 1.2 μg/ml     
  Knipholone anthrone (7)   4.1 and 3.6 μg/ml     
  10-Acetonylknipholone cyclooxanthrone (8)   4.4 and 3.1 μg/ml     
  Knipholone (9)   55.14 and 60.2% at 100 and 200 m/kg/day Good Pb 2000 [74]
  Dianellin (10)   53.77 at 100 mg/kg/day     
  2-acetyl-1-hydroxy-8-methoxy-3-methylnaphthalene (11) Root 15.4 μg/ml Moderate Pb 3D7 NE [98]
  10-(chrysophanol-7′-yl)-10-(ξ)- hydroxychrysophanol-9-anthrone (12)   0.260 μg/ml Very good    
Aloe otallensis 2,8-O,O-di(β-D-glucopyranosyl)-1,2,8-trihydroxy-3-methylnaphthalene (13) Leave latex 47.29% at 100 mg/kg/day Moderate Pb NE [72]
Otostegia integrifolia Otostegindiol (14) leave 50.13, 65.58 & 73.16% at 25, 50 & 100 mg/kg/day Very good Pb ANKA NE [94]
Aloe debrana (E)-2-(1-hydroxy-2-methylpropyl)-8-(6'-O-cinnamoyl)-β-D-glucopyranosyl-7-methoxy-5-Methylchromone (HCGMM) (15) Leave latex 63.13% at 100 mg/kg/day Very good Pb 500 [52]
  Aloin (16)   78.31% at 100 mg/kg/day     
Aloe macrocarpa Aloinoside (17) Leave latex 79.1, 90.9 & 100% at 100, 200 & 400 mg/kg/day Very good Pb ANKA 2000 [73]
Aloe pulcherrima Aloesaponarin I (18) Root 7.8 μg/ml Good Pb D6 NE [99]
  Aloesaponarin I (19)   5.0 μg/ml     
Dodonaea angustifolia Pinocembrin (20) Leave 77.03% and 81.00% at 20 and 40 mg/kg/day Very good Pb NE [60]
  Santin (21) Leave 80.95% and 85.50% at 50 and     
    100 mg/kg     
  (2-hydroxy-15,16-epoxyceloda-3,13,14-trien-18-oic acid) (22) Leave 60.35% and     
    70.81% at 20 and 40 mg/kg     
Aloe pulcherrima 7-hydroxyaloin (23) Leave latex 56.2% at 200 mg/kg/day Good Pb 2000 [100]