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Table 1 Summary of study population characteristics

From: Haematological profile of malaria patients with G6PD and PKLR variants (erythrocytic enzymopathies): a cross-sectional study in Thailand

 

Number of Enrolled

Myanmarese (%)

Cambodian (%)

Karen (%)

Laotians (%)

Mons (%)

Thais (%)

Unknown (%)

Total (%)

Ethnicity

Malaria patients

189 (74.1)

8 (3.1)

16 (6.3)

2 (0.8)

4 (1.6)

35 (13.7)

1 (0.4)

255

Age

Median ± IQR (years)

25.0 ± 15.0

24.5 ± 6.0

20.0 ± 7.0

28.0

21.5 ± 6.0

29.5 ± 15.0

16.0

25.0 ± 14.0

Range (years)

14–057

19–30

14–40

24–32

19–26

16–60

16

14–60

Sex

Male (%)

182 (96.3)

8 (100)

16 (100)

2 (100.0)

4 (100.0)

31 (88.6)

1 (100.0)

244 (95.7)

Female (%)

7 (3.7)

–

–

–

–

4 (11.4)

–

11 (4.3)

Plasmodium spp.

P. falciparum (%)

81 (42.9)

1 (12.5)

7 (43.8)

2 (100.0)

1 (25.0)

14 (40.0)

–

106 (41.6)

P. vivax (%)

105 (55.6)

6 (75.0)

9 (56.3)

–

3 (75.0)

21 (60.0)

1(100.0)

145 (56.9)

Co-infection (Pf + Pv) (%)

2 (1.1)

1 (12.5)

–

–

–

–

–

3 (1.2)

P. malariae (%)

1 (0.5)

–

–

–

–

–

–

1 (0.4)

G6PD (n = 45)

G6PD deficiency (%)

19 (10.1)

M:18, F:1

1 (12.5)

M:1

3 (18.8)

M:3

–

–

5 (14.3)

M: 5

–

28 (11.0)

M: 27 (11.1), F: 1 (9.1)

G6PD intermediate (%)

11 (5.8)

M: 10, F: 1

–

1 (6.3)

M: 1

–

–

5 (14.3)

M: 3, F: 2

–

17 (6.7)

M: 14 (5.7), F: 3 (27.3)

MahidolG487A mutation (%)

14 (7.4)

(Hemi: 13) (Homo: 1)

–

2 (12.5)

(Hemi: 2)

–

–

2 (5.7)

(Hemi: 2)

–

18 (7.1)

(Hemi: 17, Homo: 1)

MAF

Overall

 G allele (%)

181 (92.3)

8 (100.0)

14 (87.5)

2 (100.0)

4 (100.0)

37 (94.9)

1 (100.0)

242 (92.9)

 A allele (%)

15 (7.7)

–

2 (12.5)

–

–

2 (5.1)

–

19 (7.1)

 Male only

        

 G allele (%)

169 (92.9)

8 (100.0)

14 (87.5)

2 (100.0)

4 (100.0)

29 (93.6)

1 (100.0)

227 (93.0)

 A allele (%)

13 (7.1)

–

2 (12.5)

–

–

2 (6.4)

–

17 (7.0)

ViangchanG871A mutation (%)

–

1 (100.0) (Hemi:1)

–

–

–

2 (5.7)

(Hemi: 2)

–

3 (1.2)

(Hemi: 3)

KaipingG1388A mutation (%)

–

–

1 (6.3)

(Hemi: 1)

–

–

–

–

1 (0.4)

(Hemi: 1)

AuresT143C mutation (%)

1 (0.5)

(Hemi: 1)

–

–

–

–

 

–

1 (0.4)

(Hemi: 1)

Unknown mutation (%)

4 (2.1)

–

–

–

–

1 (2.9)

–

5 (2.0)

PKLR (n = 12)

PKLRR41Q mutation (%)

9 (4.8)

1 (12.5)

–

–

–

2 (5.7)

–

12 (4.7)

Genotype G A (%)

8 (88.9)

1 (100.0)

–

–

–

2 (100.0)

–

11 (4.3)

Genotype A A (%)

1 (11.1)

–

–

–

–

–

–

1 (0.4)

MAF

 G allele (%)

368 (97.4)

15 (93.7)

32 (100.0)

4 (100.0)

8 (100.0)

68 (97.1)

2 (100.0)

497 (97.5)

 A allele (%)

10 (2.6)

1 (6.3)

–

–

–

2 (2.9)

–

13 (2.6)

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Malaria Journal

ISSN: 1475-2875

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