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Table 1 Summary of study population characteristics

From: Haematological profile of malaria patients with G6PD and PKLR variants (erythrocytic enzymopathies): a cross-sectional study in Thailand

  Number of Enrolled Myanmarese (%) Cambodian (%) Karen (%) Laotians (%) Mons (%) Thais (%) Unknown (%) Total (%)
Ethnicity Malaria patients 189 (74.1) 8 (3.1) 16 (6.3) 2 (0.8) 4 (1.6) 35 (13.7) 1 (0.4) 255
Age Median ± IQR (years) 25.0 ± 15.0 24.5 ± 6.0 20.0 ± 7.0 28.0 21.5 ± 6.0 29.5 ± 15.0 16.0 25.0 ± 14.0
Range (years) 14–057 19–30 14–40 24–32 19–26 16–60 16 14–60
Sex Male (%) 182 (96.3) 8 (100) 16 (100) 2 (100.0) 4 (100.0) 31 (88.6) 1 (100.0) 244 (95.7)
Female (%) 7 (3.7) 4 (11.4) 11 (4.3)
Plasmodium spp. P. falciparum (%) 81 (42.9) 1 (12.5) 7 (43.8) 2 (100.0) 1 (25.0) 14 (40.0) 106 (41.6)
P. vivax (%) 105 (55.6) 6 (75.0) 9 (56.3) 3 (75.0) 21 (60.0) 1(100.0) 145 (56.9)
Co-infection (Pf + Pv) (%) 2 (1.1) 1 (12.5) 3 (1.2)
P. malariae (%) 1 (0.5) 1 (0.4)
G6PD (n = 45) G6PD deficiency (%) 19 (10.1)
M:18, F:1
1 (12.5)
M:1
3 (18.8)
M:3
5 (14.3)
M: 5
28 (11.0)
M: 27 (11.1), F: 1 (9.1)
G6PD intermediate (%) 11 (5.8)
M: 10, F: 1
1 (6.3)
M: 1
5 (14.3)
M: 3, F: 2
17 (6.7)
M: 14 (5.7), F: 3 (27.3)
MahidolG487A mutation (%) 14 (7.4)
(Hemi: 13) (Homo: 1)
2 (12.5)
(Hemi: 2)
2 (5.7)
(Hemi: 2)
18 (7.1)
(Hemi: 17, Homo: 1)
MAF
Overall
 G allele (%) 181 (92.3) 8 (100.0) 14 (87.5) 2 (100.0) 4 (100.0) 37 (94.9) 1 (100.0) 242 (92.9)
 A allele (%) 15 (7.7) 2 (12.5) 2 (5.1) 19 (7.1)
 Male only         
 G allele (%) 169 (92.9) 8 (100.0) 14 (87.5) 2 (100.0) 4 (100.0) 29 (93.6) 1 (100.0) 227 (93.0)
 A allele (%) 13 (7.1) 2 (12.5) 2 (6.4) 17 (7.0)
ViangchanG871A mutation (%) 1 (100.0) (Hemi:1) 2 (5.7)
(Hemi: 2)
3 (1.2)
(Hemi: 3)
KaipingG1388A mutation (%) 1 (6.3)
(Hemi: 1)
1 (0.4)
(Hemi: 1)
AuresT143C mutation (%) 1 (0.5)
(Hemi: 1)
  1 (0.4)
(Hemi: 1)
Unknown mutation (%) 4 (2.1) 1 (2.9) 5 (2.0)
PKLR (n = 12) PKLRR41Q mutation (%) 9 (4.8) 1 (12.5) 2 (5.7) 12 (4.7)
Genotype G A (%) 8 (88.9) 1 (100.0) 2 (100.0) 11 (4.3)
Genotype A A (%) 1 (11.1) 1 (0.4)
MAF
 G allele (%) 368 (97.4) 15 (93.7) 32 (100.0) 4 (100.0) 8 (100.0) 68 (97.1) 2 (100.0) 497 (97.5)
 A allele (%) 10 (2.6) 1 (6.3) 2 (2.9) 13 (2.6)