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Table 3 Performance characteristics of two malaria rapid diagnostic tests, Aweil, South Sudan, 2019*

From: Evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria and prevalence of pfhrp2/3 deletions in Aweil, South Sudan

Characteristic test Microscopy as gold standard PCR as gold standard
N Value 95% CI N Value 95% CI
Sensitivity
 pLDH 471 99.4 98.1–99.9 542 97.0 95.3–98.3
 HRP2 471 99.2 97.8–99.8 542 96.5 94.6–97.9
Specificity
 pLDH 329 55.0 49.5–60.5 258 65.1 59.0–70.9
 HRP2 329 61.7 56.2–67.0 258 72.9 67.0–78.2
PPV
 pLDH 616 76.0 72.4–79.3 616 85.4 82.3–88.1
 HRP2 593 78.8 75.2–82.0 593 88.2 85.3–90.7
NPV
 pLDH 184 98.4 95.3–99.7 184 91.3 86.3–94.9
 HRP2 207 98.1 95.1–99.5 207 90.8 86.0–94.4
  1. *PPV positive predictive value, NPV negative predictive value
  2. For sensitivity, N represents all true positives by microscopy or PCR; for specificity, N represents all true negatives by microscopy or PCR; for PPV, N represents all RDT test positives; and for NPV, N represents all RDT test negatives