Evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria and prevalence of pfhrp2/3 deletions in Aweil, South Sudan

Table 5 Performance characteristics of two malaria rapid diagnostic tests, stratified by recent treatment for malaria, Aweil, South Sudan, 2019^*

	Malaria treatment in prior 2 months	Microscopy as gold standard			PCR as gold standard
	Malaria treatment in prior 2 months	N^*	Proportion	95% CI	N^*	Proportion	95% CI
Sensitivity
pLDH	No	318	99.1	97.3–99.8	356	96.3	93.8–98.0
pLDH	Yes	153	100	97.6–100	186	98.4	95.4–99.7
HRP2	No	318	98.7	96.8–99.7	356	95.5	92.8–97.4
HRP2	Yes	153	100	97.6–100	186	98.4	95.4–99.7
Specificity
pLDH	No	225	65.8	59.2–72.0	187	73.8	66.9–79.9
pLDH	Yes	104	31.7	22.9–41.6	71	42.3	30.6–54.6
HRP2	No	225	72.9	66.6–78.6	187	81.3	74.9–86.6
HRP2	Yes	104	37.5	28.2–47.5	71	50.7	38.6–62.8

^*For sensitivity, N represents all true positives by microscopy or PCR; for specificity, N represents all true negatives by microscopy or PCR

ISSN: 1475-2875