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Table 5 Performance characteristics of two malaria rapid diagnostic tests, stratified by recent treatment for malaria, Aweil, South Sudan, 2019*

From: Evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria and prevalence of pfhrp2/3 deletions in Aweil, South Sudan

  Malaria treatment in prior 2 months Microscopy as gold standard PCR as gold standard
N* Proportion 95% CI N* Proportion 95% CI
Sensitivity
pLDH No 318 99.1 97.3–99.8 356 96.3 93.8–98.0
Yes 153 100 97.6–100 186 98.4 95.4–99.7
HRP2 No 318 98.7 96.8–99.7 356 95.5 92.8–97.4
Yes 153 100 97.6–100 186 98.4 95.4–99.7
Specificity
pLDH No 225 65.8 59.2–72.0 187 73.8 66.9–79.9
Yes 104 31.7 22.9–41.6 71 42.3 30.6–54.6
HRP2 No 225 72.9 66.6–78.6 187 81.3 74.9–86.6
Yes 104 37.5 28.2–47.5 71 50.7 38.6–62.8
  1. *For sensitivity, N represents all true positives by microscopy or PCR; for specificity, N represents all true negatives by microscopy or PCR