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Table 3. Comparison of prevalence of drug resistance molecular markers in parasites between mosquitoes and human hosts

From: Temporal trends in molecular markers of drug resistance in Plasmodium falciparum in human blood and profiles of corresponding resistant markers in mosquito oocysts in Asembo, western Kenya

Gene

SNP

Mosquitoes

Human blood

P value

Prevalence (95% CI)

Prevalence (95% CI)

Pfdhfr

 

n = 62

n = 212

 

N51I

98.4 (91.3, 100)

100 (98.3, 100)

0.226

C59R

95.2 (86.5, 99.0)

97.2 (93.9, 99.0)

0.689

S108N

98.4 (91.3, 100)

100 (98.3, 100)

0.226

I164L

0 (0, 5.8)

0.9 (0.1, 3.4)

1.000

Pfdhps

 

n = 58

n = 210

 

S436H

1.7 (0, 9.2)

10.5 (6.7, 15.4)

0.059

A437G

98.3 (90.8, 100)

100 (98.3, 100)

0.216

K540E

98.3 (90.8, 100)

99.5 (97.4, 100)

0.387

A581G

1.7 (0, 9.2)

1.0 (0.1, 3.4)

1.000

Pfcrt

 

n = 48

n = 208

 

M74I

27.1 (15.3, 41.9)

17.3 (12.4, 23.2)

0.153

N75D/E

31.3 (18.7, 46.3)

18.3 (13.3, 24.2)

0.051

K76T

31.3 (18.7, 46.3)

18.3 (13.3, 24.2)

0.051

Pfmdr1

 

n = 65

n = 207

 

N86Y

9.2 (3.5, 19.0)

10.1(6.4, 15.1)

1.000

Y184F

43.1 (30.9, 56.0)

52.2 (45.1, 59.2)

0.255

D1246Y

10.1 (4.8, 22.6)

13.5 (9.2, 19.0)

0.830

  1. P values in bold indicate marginal differences (0.05 ≤ p < 0.10).