Fig. 3

3D representation of the nasal cast and spray device with the nasal delivery place (picture curtesy of Aptar pharma). a 3D representation of the experimental set-up of artesunate drug deposition study. b 3D representation of the experimental set-up of artesunate drug deposition study with the blocks of the nasal cast and corresponding nasal regions. block 1 = nose, nasal valve, and frontal sinuses; block 2 = maxillary sinuses, frontal sinuses, nasal floor, turbinates, and ethmoids; block 3 = maxillary sinuses, sphenoids, nasal floor, ethmoids and turbinates; block 4: Sphenoids and nasopharynx