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Table 1 The growth and % survival results in RSA0−3 h assay of transgenic parasite lines, their parental strain and control of ART-resistance parasite (mean ± SD)

From: Apicoplast ribosomal protein S10-V127M enhances artemisinin resistance of a Kelch13 transgenic Plasmodium falciparum

Parasite sample

Growth

P value

RSA0–3 h (%), 20 nM DHA

P value

RSA0–3 h (%), 700 nM DHA

P value

3D7

5.25 ± 1.63

 

4.19 ± 2.67

 

0.44 ± 0.27

 

F MT _3D7

5.08 ± 0.94

> 0.9999

3.58 ± 1.68

> 0.9999

0.51 ± 0.40

> 0.9999

A MT_3D7

3.89 ± 1.01

0.7859

5.42 ± 2.18

> 0.9999

0.43 ± 0.30

> 0.9999

K MT _3D7

3.57 ± 0.84

0.5384

20.88 ± 6.42

0.0023*

13.26 ± 3.73

0.0001**

K MT F MT _3D7

4.70 ± 1.24

0.9964

21.25 ± 5.87

0.0017*

13.80 ± 4.18

< 0.0001***

K MT F MT A MT _3D7

4.27 ± 0.68

0.9442

34.29 ± 8.26

< 0.0001**

24.23 ± 0.83

< 0.0001***

MRA1240

5.99 ± 3.14

0.9864

62.36 ± 11.46

< 0.0001**

30.80 ± 8.88

< 0.0001***

  1. Each experiment was repeated for 5–6 times independently, with each group comprised of two technical repetitions. One-way ANOVA with Tukey’s multiple comparisons test was performed at 95% CI. The P-values of the comparison of each strain to the 3D7 line are showed