Fig. 1

A Relative positions of SNPs on ATP2B4 gene. Schematic view of the ATP2B4 gene, mRNA and protein showing the genomic location of all SNPs associated with malaria altered susceptibility and one SNP (rs7551442) associated with altered erythrocytic MCHC. Boxes represent coding region (exons). Boxes in yellow represent the exons that form the 5’ and 3’ untranslated regions. Boxes in green represent the exons that code for the translated protein. B Linkage disequilibrium analysis of ATP2B4 SNPs associated with malaria protection and PMCA4b function. LD analysis was done using LDlink on the 1000 genome data of Gambian population. Matrix was created to describe the relationship between the SNPs as a function of R² presented. R² between each pair of SNPs are color coded according to strength of the LD (R² = 1 to 0.9, dark blue or ‘strong’; R² = 0.8 to 0.7, medium blue or ‘moderate’ and R² = 0.6, light blue for ‘weak’