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Table 4 Association between OP and IgG1 to merozoite P. falciparum antigens

From: Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes: implications for control of asymptomatic malaria infections

Opsonic phagocytosis

Coef.

95% CI

P value

 

Model 1: OP THP-1

 IgG1_AMA1

   

Number of observations = 87

  High

9.38

2.38;16.39

0.009

Adj R2 = 0.30

  Low (reference)

 IgG1_MSP1

  High

7.71

1.81;13.61

0.010

 

  Low (reference)

 IgG1_MSP3

  High

−1.19

−8.40;6.00

0.744

 

  Low (reference)

 IgG1_MSP2-3D7

  High

3.72

−3.48;10.93

0.311

 

  Low (reference)

 IgG1_MSP2-FC27

  High

5.54

−1.91;13

0.145

 

  Low (reference)

 IgG1_GLURP-R0

  High

0.06

−5.69;5.82

0.983

 

  Low (reference)

 IgG1_GLURP-R2

  High

−2.48

−9.61;4.64

0.494

 

  Low (reference)

Model 2: OP Neutrophils

 IgG1_AMA1

   

Number of observations = 87

  High

19.87

9.33;30.40

0.0001

Adj R2 = 0.27

  Low (reference)

 IgG1_MSP1

  High

13.21

4.33;22.09

0.004

 

  Low (reference)

 IgG1_MSP3

  High

−5.88

−16.72;4.94

0.287

 

  Low (reference)

 IgG1_MSP2-3D7

  High

1.69

−9.15;12.53

0.760

 

  Low (reference)

 IgG1_MSP2-FC27

  High

5.15

−12.90;4.41

0.368

 

  Low (reference)

 IgG1_GLURP-R0

  High

−4.24

−13.39;8.06

0.367

 

  Low (reference)

 IgG1_GLURP-R2

  High

−2.66

−16.64;5.12

0.626

 

  Low (reference)

  1. This table presents the generalized linear model obtained through the control variables bednet use, sex, and HbS. The reference groups corresponded to the low level of IgG1 specific to each merozoite antigen determined according to the median. IgG1 to merozoite P. falciparum antigens were quantified at 18 months of age
  2. In bold: significant P value at the 0.05 threshold