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Fig. 2 | Malaria Journal

Fig. 2

From: Multicohort transcriptome analysis of whole blood identifies robust human response signatures in Plasmodium falciparum infections

Fig. 2

Functional enrichment of DEGs and hub gene identification. A GO enrichment analysis of 887 differentially expressed genes between the malaria-infected and noninfected groups in the discovery cohorts. ‘Gene ratio’ is the percentage of total DEGs in the given GO term. The size of the dots represents the number of genes in DEGs associated with the GO term and the colour of the dots represents the P-adjusted values. B The top 10 hub genes were identified based on the degree ranking method using the cytoHubba plug-in in Cytoscape. The rank of the connection degree is represented by different colours (from red to yellow). Genes in blue indicate downregulated genes, while genes in black indicate upregulated genes in the malaria-infected group

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