Table 2 Estimated in situ limit of detection of HRP2-based rapid diagnostic tests used as estimated from logistic dose–response model: Tanzania, 2017
Village | Number enrolled(% of all) | RDT type | RDT positive (%) | HRP2 concentration at indicated probability of a positive test (ng/mL, 95% confidence interval) | |||
|---|---|---|---|---|---|---|---|
50% | 75% | 90% | 95% | ||||
Herembe | 473 (6.8%) | pLDH/HRP2 | 150 (31.7%) | 1.53 (1.2–2.1) | 4.28 (2.9–6.5) | 11.95 (6.6–20) | 24.00 (11–42) |
Kigege | 485 (7.0%) | pLDH/HRP2 | 166 (34.2%) | 1.29 (1–1.7) | 2.74 (2–3.8) | 5.82 (3.6–8.6) | 9.76 (5.3–15) |
Kaseme | 545 (7.9%) | pLDH/HRP2 | 109 (20.0%) | 1.17 (0.88–1.7) | 2.87 (1.8–4.6) | 6.96 (3.6–12) | 12.71 (5.3–23) |
Mwamila | 481 (6.9%) | pLDH/HRP2 | 189 (39.3%) | 1.07 (0.85–1.4) | 2.29 (1.7–3.2) | 4.91 (3.1–7.2) | 8.18 (4.6–13) |
Kitunguli | 399 (5.7%) | HRP2 | 170 (42.6%) | 0.93 (0.63–1.5) | 5.96 (3.2–12) | 38.41 (14–101) | NA (33.0-NA) |
Mkowela | 408 (5.9%) | HRP2 | 159 (39.0%) | 0.79 (0.65–0.98) | 1.32 (1–1.7) | 2.24 (1.5–3.1) | 3.19 (2–4.5) |
Nyankoronko | 532 (7.7%) | pLDH/HRP2 | 232 (43.6%) | 0.78 (0.67–0.95) | 1.43 (1.1–1.8) | 2.59 (1.8–3.4) | 3.88 (2.5–5.3) |
Kasenga | 474 (6.8%) | pLDH/HRP2 | 201 (42.4%) | 0.78 (0.67–0.93) | 1.17 (0.96–1.4) | 1.76 (1.3–2.2) | 2.33 (1.6–3) |
Nyangalamila | 489 (7.0%) | pLDH/HRP2 | 118 (24.1%) | 0.68 (0.57–0.86) | 1.07 (0.83–1.4) | 1.69 (1.1–2.3) | 2.30 (1.4–3.2) |
Katale | 540 (7.8%) | pLDH/HRP2 | 128 (23.7%) | 0.68 (0.56–0.87) | 1.09 (0.81–1.5) | 1.75 (1.1–2.4) | 2.43 (1.4–3.5) |
Lundo | 410 (5.9%) | pLDH/HRP2 | 112 (27.3%) | 0.65 (0.55–0.78) | 0.90 (0.73–1.1) | 1.27 (0.94–1.6) | 1.60 (1.1–2.1) |
Chiulu | 435 (6.3%) | HRP2 | 116 (26.7%) | 0.48 (0.42–0.59) | 0.69 (0.55–0.86) | 0.97 (0.7–1.2) | 1.23 (0.81–1.6) |
Lukumbule | 469 (6.8%) | HRP2 | 204 (43.5%) | 0.42 (0.37–0.48) | 0.59 (0.5–0.7) | 0.83 (0.65–1.0) | 1.05 (0.76–1.3) |
Mtawarawa | 397 (5.7%) | HRP2 | 152 (38.3%) | 0.26 (0.21–0.33) | 0.41 (0.31–0.55) | 0.66 (0.43–0.92) | 0.92 (0.53–1.3) |
Mkunwa | 404 (5.8%) | HRP2 | 142 (35.1%) | 0.18 (0.14–0.24) | 0.29 (0.21–0.4) | 0.48 (0.3–0.7) | 0.68 (0.37–1.0) |