Table 1 IC50 of (1)–(4) and its precursors for Plasmodium falciparum 3D7 (Pf3D7) and IPC5202 (Pf5202) at 72 h incubation
Compound | IC50 of Pf3D7 (µM) | IC50 of Pf5202 (µM) |
|---|---|---|
phen | 4.27 ± 0.05 |  > 100 |
4,4-bipy |  > 100 |  > 100 |
Cu(NO3)2·3H2O | 46.10 ± 4.29 | 49.37 ± 2.30 |
Zn(NO3)2·6H2O |  > 100 |  > 100 |
1 | 3.51 ± 0.47 | 17.87 ± 2.73 |
2 | 4.44 ± 0.53 |  > 100 |
3 | 0.90 ± 0.12 | 2.21 ± 0.02 |
4 | 3.93 ± 0.18 |  > 100 |
CQ | 0.03 ± 0.01 |  > 100 |
ART | 0.04 ± 0.01 |  > 100 |