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Table 4 The fold change in ROS induced by phen and (1)–(4) on Pf5202. Hydrogen peroxide (H2O2) is used as positive control

From: Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action

Compound

24 h

48 h

72 h

0.2 µM

1.0 µM

5.0 µM

25.0 µM

0.2 µM

1.0 µM

5.0 µM

25.0 µM

0.2 µM

1.0 µM

5.0 µM

25.0 µM

phen

1.06 ± 0.06

1.08 ± 0.09

0.91 ± 0.05

0.80 ± 0.04

1.78 ± 0.78

1.31 ± 0.21

1.40 ± 0.13

1.32 ± 0.31

1.35 ± 0.71

1.17 ± 0.44

1.08 ± 0.51

1.21 ± 1.25

1

1.04 ± 0.03

0.86 ± 0.04

0.59 ± 0.02

0.04 ± 0.03

0.32 ± 0.02

0.33 ± 0.05

0.72 ± 0.12

0.52 ± 0.26

1.09 ± 0.07

1.33 ± 0.41

1.69 ± 0.22

− 1.66 ± 0.63

2

1.07 ± 0.05

1.10 ± 0.09

1.00 ± 0.02

1.04 ± 0.06

− 0.54 ± 0.19

− 0.44 ± 0.25

− 0.07 ± 0.27

− 0.97 ± 1.12

0.00 ± 0.03

0.34 ± 0.04

0.16 ± 0.04

− 0.72 ± 0.02

3

0.04 ± 0.33

− 0.64 ± 0.33

− 1.32 ± 0.57

− 7.33 ± 0.59

0.52 ± 0.60

0.66 ± 0.50

2.53 ± 0.85

3.39 ± 0.66

− 0.24 ± 0.52

− 0.79 ± 0.09

8.43 ± 0.60

− 0.38 ± 0.32

4

− 0.27 ± 0.19

0.44 ± 0.25

− 0.41 ± 0.15

− 2.29 ± 0.66

− 1.53 ± 0.39

− 0.42 ± 0.38

0.43 ± 0.09

0.39 ± 0.36

− 0.03 ± 0.11

0.45 ± 0.32

0.33 ± 0.01

0.13 ± 0.05

Positive control

24 h

48 h

72 h

8 µM

40 µM

200 µM

1000 µM

8 µM

40 µM

200 µM

1000 µM

8 µM

40 µM

200 µM

1000 µM

H2O2

1.10 ± 0.04

1.16 ± 0.13

1.08 ± 0.18

1.15 ± 0.22

1.78 ± 0.16

1.54 ± 0.28

1.41 ± 0.16

1.68 ± 0.28

1.82 ± 0.15

1.17 ± 0.36

2.06 ± 0.25

3.71 ± 0.14