Fig. 1

Transcriptomic analysis of primary rhesus macaque hepatocytes infected with P. cynomolgi schizonts. Heat map (A) and multidimensional scaling (MDS) plot (B) showing sample-to-sample separation of cells infected with schizonts (Sz, in red), uninfected bystander (Negative, in grey) cells and cells from uninfected samples (Uninfected, in black). Volcano plots showing mean log₂ fold changes and -log₁₀ adjusted P_values (adj. P_value) for cells infected with schizonts in comparison to uninfected samples (C), negative cells in comparison to uninfected samples (D) and cells infected with schizonts in comparison to negative cells (E). Horizontal and vertical dotted red lines indicate adjusted P_values less than 0.05 [or − log10 (adj. P_value) greater than 1.3] and absolute log₂ fold changes greater than 1, respectively