Fig. 2
Pathway analysis of genes significantly upregulated in schizont-infected hepatocytes in comparison to uninfected samples. A Most enriched ontology clusters for genes significantly upregulated in primary rhesus macaque hepatocytes infected with P. cynomolgi schizonts. The vertical dotted red line indicates adjusted Pvalues less than 0.05 (or − log10 (adj. Pvalue) greater than 1.3). The most significantly enriched term of each ontology clusters was selected as the cluster label. B Subset of representative terms were selected to generate a network of enriched ontology clusters. Terms are represented by circle nodes with colors that shows belonging to a specific cluster. Circles nodes with similarity scores > 0.3 are linked with edges. C–L Heat maps of log2 fold changes for the 25 most upregulated genes for selected ontology clusters. Data are shown for schizont-infected and uninfected bystander (negative) cells in comparison to uninfected samples. Some annotation terms are abbreviated or modified for a purpose of presentation