Table 2 Parasite clearance kinetics (mITT population)

Parasite clearance rate (1/h)

n = 21

n = 28

n = 28

n = 25

Mean (SD)

[range]

0.20 (0.08)

[0.10 to 0.39]

0.36 (0.10)

[0.17 to 0.67]

0.40 (0.12)

[0.22 to 0.79]

0.36 (0.12)

[0.07 to 0.60]

Estimated PRR₂₄, log₁₀

n = 21

n = 28

n = 28

n = 25

Mean (SD)

[range]

2.0 (0.79)

[1.00 to 4.09]

3.76 (1.04)

[1.74 to 6.97]

4.13 (1.25)

[2.29 to 8.23]

3.73 (1.30)

[0.70 to 6.30]

Estimated PRR₄₈, log₁₀

n = 21

n = 28

n = 28

n = 25

Mean (SD)

[range]

4.08 (1.59)

[1.99 to 8.18]

7.52 (2.08)

[3.48 to 13.94]

8.26 (2.50)

[4.57 to 16.46]

7.46 (2.60)

[1.41 to 12.60]

Estimated PRR₇₂, log₁₀

n = 21

n = 28

n = 28

n = 25

Mean (SD)

[range]

6.12 (2.38)

[2.99 to 12.27]

11.28 (3.12)

[5.22 to 20.90]

12.39 (3.75)

[6.86 to 24.69]

11.20 (3.90)

[2.11 to 18.90]

PC₅₀, h

n = 21

n = 28

n = 28

n = 25

Mean (SD)

[range]

14.07 (5.60)

[6.9 to 25.3]

7.74 (4.64)

[0.4 to 19.9]

7.78 (3.79)

[0.5 to 15.0]

9.47 (7.98)

[0.4 to 33.3]

T_PC50, h

n = 21

n = 28

n = 28

n = 25

Geometric mean point estimate (95% CI)

3.79 (3.29, 4.38)

1.99 (1.75, 2.25)

1.81 (1.60, 2.05)

2.09 (1.84, 2.39)

PC₉₉, h

n = 21

n = 28

n = 28

n = 25

Mean (SD)

[range]

36.92 (9.99)

[24.6 to 56.0]

19.33 (6.11)

[6.6 to 33.1]

18.34 (5.52)

[5.6 to 29.4]

22.95 (17.07)

[6.9 to 90.1]

T_PC99, h

n = 21

n = 28

n = 28

n = 25

Geometric mean point estimate (95% CI)

25.21 (21.84, 29.10)

13.20 (11.66, 14.94)

12.05 (10.64, 13.65)

13.91 (12.20, 15.87)