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Fig. 6 | Malaria Journal

Fig. 6

From: Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors

Fig. 6

Average difference of model-predicted fluxes transporting the listed metabolites in PA21A092-treated and KAE609-treated mutants. The flux difference was averaged to capture ring (1–18 h), trophozoite (19–32 h), and schizont (33–48 h) stages of blood-stage malaria parasites. Prior to taking the average of difference, the flux-difference value of a metabolite was normalized by its median value in the Dd2 wildtype. A negative (or positive) value, under the ring, trophozoite (troph), or schizont column, suggests that the metabolic flux is more negative (or positive) in PA21A092-treated mutants as compared to the KAE609-treated mutants. The trend lines capture gross difference in metabolic fluxes during ring, trophozoite, and schizont stages of the two mutants

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