Fig. 6From: Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitorsAverage difference of model-predicted fluxes transporting the listed metabolites in PA21A092-treated and KAE609-treated mutants. The flux difference was averaged to capture ring (1–18 h), trophozoite (19–32 h), and schizont (33–48 h) stages of blood-stage malaria parasites. Prior to taking the average of difference, the flux-difference value of a metabolite was normalized by its median value in the Dd2 wildtype. A negative (or positive) value, under the ring, trophozoite (troph), or schizont column, suggests that the metabolic flux is more negative (or positive) in PA21A092-treated mutants as compared to the KAE609-treated mutants. The trend lines capture gross difference in metabolic fluxes during ring, trophozoite, and schizont stages of the two mutantsBack to article page